The Cain House was a waterfront inn built by Alexander Creel in 1850 when Saint Marys was established. Creel was the founder of Saint Marys and a proponent in the formation of Pleasants County. The hotel is located where George Washington landed on his journey down the Ohio River in 1770. The landmark is named for Zachariah Cain, who operated a hotel and tavern in the building from 1875 well into the early 20th century. In 1957, the Masons acquired the Cain House for use as a lodge.
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